What is the correct epinephrine dosing interval in adult ACLS?

• A. 2 mg every 5-6 minutes
• B. 0.5 mg every minute
• C. 1 mg every 3-5 minutes (every other pulse check)
• D. 1 mg every minute

Answer: (C)

Epinephrine is given in adult ACLS to improve perfusion during CPR by increasing coronary and cerebral perfusion pressure, so the dosing interval is set to 1 mg IV or IO every 3–5 minutes. This schedule fits with the rhythm of resuscitation, allowing repeated administration while continuing chest compressions and reassessment. The goal is to maintain ongoing support without overloading the system with too frequent dosing. Other patterns don’t fit because they either change the amount per dose or the timing: 2 mg every 5–6 minutes is not the standard per-dose amount; 0.5 mg every minute moves the dose and interval away from guideline recommendations; 1 mg every minute is too frequent. Remember the recommended approach is 1 mg every 3–5 minutes.